| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein kinase TTK |
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| Ligand | BDBM190364 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Mps-1 Kinase Assay |
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| pH | 7.7±n/a |
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| IC50 | 20600±n/a nM |
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| Comments | extracted |
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| Citation |  Schirok, H; Schulze, V; Kosemund, D; Briem, H; Bader, B; Bömer, U; Wengner, AM; Siemeister, G; Lienau, P Substituted triazolopyridines US Patent US9670202 Publication Date 6/6/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein kinase TTK |
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| Name: | Dual specificity protein kinase TTK |
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| Synonyms: | Dual specificity protein kinase (TTK) | Dual specificity protein kinase TTK (MPS1) | MPS1 | MPS1L1 | Monopolar Spindle 1 (MPS1) | Monopolar Spindle 1 (Mps-1) | Monopolar Spindle 1 Kinase (MPS1) | Phosphotyrosine picked threonine-protein kinase (MPS1) | TTK | TTK_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 97086.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P33981 |
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| Residue: | 857 |
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| Sequence: | MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMAN
NPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELK
AIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEML
EIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARF
LYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQ
TSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKT
ESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQ
KHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQ
LSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVF
QVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYM
VMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGML
KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSL
GCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRI
SIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGE
SHNSSSSKTFEKKRGKK
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| BDBM190364 |
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| n/a |
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| Name | BDBM190364 |
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| Synonyms: | US9670202, Example01.07 4-(2-{[2-(cyclopropylmethoxy)-4-(diethylcarbamoyl)phenyl]amino}[1,2,4]-triazolo[1,5-a]pyridin-6-yl)-N-(4-fluorobenzyl)piperazine-1-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C33H39FN8O3 |
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| Mol. Mass. | 614.713 |
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| SMILES | CCN(CC)C(=O)c1ccc(Nc2nc3ccc(cn3n2)N2CCN(CC2)C(=O)NCc2ccc(F)cc2)c(OCC2CC2)c1 |
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| Structure | 
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