| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
|---|
| Ligand | BDBM11621 |
|---|
| Substrate/Competitor | BDBM10856 |
|---|
| Meas. Tech. | CA Inhibition Assay |
|---|
| Ki | 0.8±n/a nM |
|---|
| Citation |  Ilies, MA; Vullo, D; Pastorek, J; Scozzafava, A; Ilies, M; Caproiu, MT; Pastorekova, S; Supuran, CT Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives. J Med Chem46:2187-96 (2003) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Carbonic anhydrase 2 |
|---|
| Name: | Carbonic anhydrase 2 |
|---|
| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 29250.71 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00918 |
|---|
| Residue: | 260 |
|---|
| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
|
|
|
|---|
| BDBM11621 |
|---|
| BDBM10856 |
|---|
| Name | BDBM11621 |
|---|
| Synonyms: | 2-N-(4-amino-3-fluorobenzene)-1,3,4-thiadiazole-2,5-disulfonamide | 5-(4-Amino-3-fluorobenzenesulfonamido)-1,3,4-thiadiazole-2-sulfonamide | aminobenzolamide 17b |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C8H8FN5O4S3 |
|---|
| Mol. Mass. | 353.374 |
|---|
| SMILES | Nc1ccc(cc1F)S(=O)(=O)Nc1nnc(s1)S(N)(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
