| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 1 |
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| Ligand | BDBM325281 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Ubitquin-Rhodamine 110 Assay for USP1 Activity |
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| IC50 | <0.002±n/a nM |
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| Citation |  Buckmelter, AJ; Ioannidis, S; Follows, B; Gustafson, G; Wang, M; Caravella, JA; Wang, Z; Fritzen, EL; Lin, J Purinones as ubiquitin-specific protease 1 inhibitors US Patent US10189841 Publication Date 1/29/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin carboxyl-terminal hydrolase 1 |
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| Name: | Ubiquitin carboxyl-terminal hydrolase 1 |
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| Synonyms: | Deubiquitinating enzyme 1 | UBP1_HUMAN | USP1 | Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48Â | Ubiquitin thioesterase 1 | Ubiquitin-specific-processing protease 1 | hUBP |
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| Type: | PROTEIN |
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| Mol. Mass.: | 88191.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_104169 |
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| Residue: | 785 |
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| Sequence: | MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQV
VPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKK
EALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRR
LLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPK
EEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQT
RSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGK
ITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQ
IGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKT
EMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGL
EFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKV
TDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNK
KNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSD
QTGINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLL
FYKKL
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| BDBM325281 |
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| n/a |
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| Name | BDBM325281 |
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| Synonyms: | 4-fluoro-N- | US10189841, Compound I-487 | US10399980, Compound I-487 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H31FN6O2 |
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| Mol. Mass. | 454.5403 |
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| SMILES | CC(C)NC(=O)N1CCC(F)(Cn2c3nc(ncc3[nH]c2=O)-c2ccccc2C(C)C)CC1 |
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| Structure | 
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