| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) |
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| Ligand | BDBM325614 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HTRF Assay |
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| IC50 | <1±n/a nM |
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| Citation |  Amari, G; Armani, E; Blackaby, W; Van De Poeol, H; Baker-Glenn, C; Trivedi, N Aminoester derivatives US Patent US9636336 Publication Date 5/2/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) |
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| Name: | Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) |
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| Synonyms: | DPDE4 | PDE4B | PDE4B2 | PDE4B_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) | phosphodiesterase 4B2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 64320.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07343-2 |
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| Residue: | 564 |
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| Sequence: | MKEHGGTFSSTGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQ
LETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPT
QKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNI
FNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAA
DVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE
SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTM
VETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDK
ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWY
QSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVID
PENRDSLGETDIDIATEDKSPVDT
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| BDBM325614 |
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| n/a |
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| Name | BDBM325614 |
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| Synonyms: | US9636336, Example 4 | US9636336, Example 55 | US9636336, Example 56 | [1-[3-(cyclopropylmethoxy)-4-methoxy-phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl]5-[[[2-[(1-methyl-4-piperidyl)methoxy]-2-oxo-1-phenyl-ethyl]amino]methyl]thiophene-2-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C39H43Cl2N3O7S |
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| Mol. Mass. | 768.746 |
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| SMILES | COc1ccc(cc1OCC1CC1)C(Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1ccc(CNC(C(=O)OCC2CCN(C)CC2)c2ccccc2)s1 |
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| Structure | 
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