| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) |
|---|
| Ligand | BDBM325607 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | HTRF Assay |
|---|
| IC50 | <1±n/a nM |
|---|
| Citation |  Amari, G; Armani, E; Blackaby, W; Van De Poeol, H; Baker-Glenn, C; Trivedi, N Aminoester derivatives US Patent US9636336 Publication Date 5/2/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) |
|---|
| Name: | Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) |
|---|
| Synonyms: | DPDE4 | PDE4B | PDE4B2 | PDE4B_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) | phosphodiesterase 4B2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 64320.36 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q07343-2 |
|---|
| Residue: | 564 |
|---|
| Sequence: | MKEHGGTFSSTGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQ
LETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPT
QKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNI
FNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAA
DVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE
SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTM
VETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDK
ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWY
QSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVID
PENRDSLGETDIDIATEDKSPVDT
|
|
|
|---|
| BDBM325607 |
|---|
| n/a |
|---|
| Name | BDBM325607 |
|---|
| Synonyms: | US9636336, Example 18 | US9636336, Example 77 | US9636336, Example 78 | [(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl]5-[[[2-[[(3S)-1-methylpyrrolidin-3-yl]methoxy]-2-oxo-1-phenyl-ethyl]amino]methyl]thiophene-2-carboxylate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C35H37Cl2N3O7S |
|---|
| Mol. Mass. | 714.655 |
|---|
| SMILES | COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1ccc(CNC(C(=O)OC[C@H]2CCN(C)C2)c2ccccc2)s1 |
|---|
| Structure | 
|
|---|
Search and Browse
