| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase Mdm2 [17-125] |
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| Ligand | BDBM326288 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FRET Assay |
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| IC50 | 353±n/a nM |
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| Citation |  Dinsmore, C; Fradera Llinas, FX; Kudale, AA; Machacek, M; Reutershan, MH; Thompson, CF; Trotter, BW; Yang, L; Altman, MD; Bogen, SL; Doll, RJ; Voss, ME Substituted pyrrolopyrimidines as HDM2 inhibitors US Patent US9637493 Publication Date 5/2/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| E3 ubiquitin-protein ligase Mdm2 [17-125] |
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| Name: | E3 ubiquitin-protein ligase Mdm2 [17-125] |
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| Synonyms: | Double minute 2 protein | E3 ubiquitin-protein ligase Mdm2 | MDM2 | MDM2_HUMAN | p53-binding protein Mdm2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 12522.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Residue 17 to 125 |
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| Residue: | 109 |
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| Sequence: | SQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVY
CSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSEN
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| BDBM326288 |
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| n/a |
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| Name | BDBM326288 |
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| Synonyms: | (R)-4-((1- cyclobutylethyl)amino)- 7-(2-fluoro-5- methylphenyl)-5-(4- (trifluoromethyl)benzyl)- 5H-pyrrolo[3,2- d]pyrimidine-2- carboxylic acid | US9637493, 1.2 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H26F4N4O2 |
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| Mol. Mass. | 526.5253 |
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| SMILES | C[C@@H](Nc1nc(nc2c(cn(Cc3ccc(cc3)C(F)(F)F)c12)-c1cc(C)ccc1F)C(O)=O)C1CCC1 |r| |
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| Structure | 
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