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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | E3 ubiquitin-protein ligase Mdm2 [17-125] | ||
| Ligand | BDBM326314 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | FRET Assay | ||
| IC50 | 247±n/a nM | ||
| Citation |  Dinsmore, C; Fradera Llinas, FX; Kudale, AA; Machacek, M; Reutershan, MH; Thompson, CF; Trotter, BW; Yang, L; Altman, MD; Bogen, SL; Doll, RJ; Voss, ME Substituted pyrrolopyrimidines as HDM2 inhibitors US Patent US9637493 Publication Date 5/2/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| E3 ubiquitin-protein ligase Mdm2 [17-125] | |||
| Name: | E3 ubiquitin-protein ligase Mdm2 [17-125] | ||
| Synonyms: | Double minute 2 protein | E3 ubiquitin-protein ligase Mdm2 | MDM2 | MDM2_HUMAN | p53-binding protein Mdm2 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 12522.24 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Residue 17 to 125 | ||
| Residue: | 109 | ||
| Sequence: |
| ||
| BDBM326314 | |||
| n/a | |||
| Name | BDBM326314 | ||
| Synonyms: | 4-(5-chloropyridin-3-yl)-5- [(trans-4- methylcyclohexyl)methyl]- 5H-pyrrolo[3,2- d]pyrimidine-2-carboxylic acid | US9637493, 4.3 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H21ClN4O2 | ||
| Mol. Mass. | 384.859 | ||
| SMILES | C[C@H]1CC[C@H](Cn2ccc3nc(nc(-c4cncc(Cl)c4)c23)C(O)=O)CC1 |r,wU:4.4,wD:1.0,(6.07,-4.33,;4.73,-3.56,;4.73,-2.02,;3.4,-1.25,;2.07,-2.02,;.73,-1.25,;.73,.29,;1.64,1.54,;.73,2.79,;-.73,2.31,;-2.07,3.08,;-3.4,2.31,;-3.4,.77,;-2.07,,;-2.07,-1.54,;-.73,-2.31,;-.73,-3.85,;-2.07,-4.62,;-3.4,-3.85,;-4.73,-4.62,;-3.4,-2.31,;-.73,.77,;-4.73,3.08,;-6.07,2.31,;-4.73,4.62,;2.07,-3.56,;3.4,-4.33,)| | ||
| Structure | 
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