Reaction Details |
| Report a problem with these data |
Target | Orexin receptor type 2 |
---|
Ligand | BDBM163869 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Human Orexin 2 Receptor Radioligand Binding Assay |
---|
Ki | 428±n/a nM |
---|
Citation | Coate, HR; Dvorak, CA; Fitzgerald, AE; Lebold, TP; Preville, C; Shireman, BT Substituted 7-azabicycles and their use as orexin receptor modulators US Patent US9637496 Publication Date 5/2/2017 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Orexin receptor type 2 |
---|
Name: | Orexin receptor type 2 |
Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
Type: | Protein |
Mol. Mass.: | 50710.53 |
Organism: | Homo sapiens (Human) |
Description: | O43614 |
Residue: | 444 |
Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
|
|
|
BDBM163869 |
---|
n/a |
---|
Name | BDBM163869 |
Synonyms: | US9062078, 4 | US9062078, 5A | US9062078, 5B | US9062078, 6 | US9475819, 4 | US9637496, 6 | US9695183, 6 |
Type | Small organic molecule |
Emp. Form. | C21H22N6O2 |
Mol. Mass. | 390.4384 |
SMILES | Cc1ccc(c(n1)C(=O)N1C2CCC1C(COc1ccccn1)C2)-n1nccn1 |TLB:15:14:12.11:9| |
Structure |
|