| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [L858R] |
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| Ligand | BDBM195873 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | EGFR kinase assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 5.83±n/a nM |
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| Comments | extracted |
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| Citation |  Li, H; Xu, Y; Zhao, Z; Liu, X; Zhou, W; Bai, F; Xue, M; Zhang, L; Zhang, Y Pteridine ketone derivative and applications thereof as EGFR, BLK, and FLT3 inhibitor US Patent US9670213 Publication Date 6/6/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Epidermal growth factor receptor [L858R] |
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| Name: | Epidermal growth factor receptor [L858R] |
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| Synonyms: | EGFR | EGFR (L858R) | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR)(L858R) | Epidermal growth factor receptor (L858R) | Epidermal growth factor receptor(L858R) | HER1 |
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| Type: | n/a |
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| Mol. Mass.: | 134323.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00533[L858R] |
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| Residue: | 1210 |
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| Sequence: | MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED
SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN
TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
APQSSEFIGA
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| BDBM195873 |
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| n/a |
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| Name | BDBM195873 |
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| Synonyms: | US9670213, Compound 018 N-(3-(2-(4-morpholinophenylamino)-7-oxo-8(7H)-pteridin-yl)phenyl) acrylamide |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23N7O3 |
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| Mol. Mass. | 469.4952 |
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| SMILES | C=CC(=O)Nc1cccc(c1)-n1c2nc(Nc3ccc(cc3)N3CCOCC3)ncc2ncc1=O |
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| Structure | 
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