| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin K |
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| Ligand | BDBM331569 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| Ki | 16.0±n/a nM |
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| Citation |  Nardi, A; Ratcliffe, P; Craan, T; Hertrampf, T; Lesch, B; Kime, R; Steinhagen, H 3-oxo-tetrahydro-furo[3,2-B]pyrrol-4(5H)-yl) derivatives I US Patent US9725459 Publication Date 8/8/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin K |
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| Name: | Cathepsin K |
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| Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
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| Type: | Enzyme |
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| Mol. Mass.: | 36975.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43235 |
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| Residue: | 329 |
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| Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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| BDBM331569 |
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| n/a |
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| Name | BDBM331569 |
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| Synonyms: | N-((S)-2-((3aS,6S,6aS)-6-chloro-3- oxotetrahydro-2H-furo[3,2-b]pyrrol-4(5H)-yl)- 1-cyclohexyl-2-oxoethyl)-5-(6- methoxypyridazin-3-yl)thiophene-2- carboxamide | US9725459, 34 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H27ClN4O5S |
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| Mol. Mass. | 519.013 |
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| SMILES | COc1ccc(nn1)-c1ccc(s1)C(=O)N[C@@H](C1CCCCC1)C(=O)N1C[C@H](Cl)[C@H]2OCC(=O)[C@@H]12 |
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| Structure | 
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