Reaction Details |
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Target | Coagulation factor IX |
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Ligand | BDBM12760 |
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Substrate/Competitor | BDBM12774 |
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Meas. Tech. | Enzyme Assay and Determination of the Inhibition Constants. |
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Ki | 6.4±n/a nM |
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Citation | Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa. Bioorg Med Chem Lett14:5263-7 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Coagulation factor IX |
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Name: | Coagulation factor IX |
Synonyms: | Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component |
Type: | Enzyme |
Mol. Mass.: | 51768.83 |
Organism: | Homo sapiens (Human) |
Description: | P00740 |
Residue: | 461 |
Sequence: | MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
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BDBM12760 |
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BDBM12774 |
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Name | BDBM12760 |
Synonyms: | 1-(3-carbamimidoylphenyl)-N-{2-fluoro-4-[5-(trifluoromethyl)-1H-1,3-benzodiazol-1-yl]phenyl}-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide | pyrazole analog 3i |
Type | Small organic molecule |
Emp. Form. | C26H16F7N7O |
Mol. Mass. | 575.4404 |
SMILES | NC(=N)c1cccc(c1)-n1nc(cc1C(=O)Nc1ccc(cc1F)-n1cnc2cc(ccc12)C(F)(F)F)C(F)(F)F |
Structure |
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