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TargetCarbonic Anhydrase XIII
LigandBDBM10881
Substrate/CompetitorBDBM10856
Meas. Tech.CA Inhibition Assay
Ki 19±n/a nM
Citation Winum JYTemperini CEl Cheikh KInnocenti AVullo DCiattini SMontero JLScozzafava ASupuran CT Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue. J Med Chem 49:7024-31 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Carbonic Anhydrase XIII
Name:Carbonic anhydrase XIII
Synonyms:CA-XIII | Carbonate dehydratase XIII | Carbonic anhydrase 13
Type:Enzyme
Mol. Mass.:29522.80
Organism:Mus musculus (mouse)
Description:Murine cloned isozyme
Residue:262
Sequence:
MARLSWGYGEHNGPIHWNELFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPASAKII
SNSGHSFNVDFDDTEDKSVLRGGPLTGNYRLRQFHLHWGSADDHGSEHVVDGVRYAAELH
VVHWNSDKYPSFVEAAHESDGLAVLGVFLQIGEHNPQLQKITDILDSIKEKGKQTRFTNF
DPLCLLPSSWDYWTYPGSLTVPPLLESVTWIVLKQPISISSQQLARFRSLLCTAEGESAA
FLLSNHRPPQPLKGRRVRASFY
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  Blast E-value cutoff:
BDBM10881
BDBM10856
NameBDBM10881
Synonyms:CHEMBL288100 | METHAZOLAMIDE | MZA3 | Methazolamide | Methazolamide (MZA) | Methazolamide, MZA | N-[(2Z)-3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene]acetamide | Sulfonamide, 2 | cid_4100 | sulfonamide 2
TypeSmall organic molecule
Emp. Form.C5H8N4O3S2
Mol. Mass.236.272
SMILESCC(=O)N=c1sc(nn1C)S(N)(=O)=O |w:3.2|
Structure
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