| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM8465 |
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| Substrate/Competitor | Unknown |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| Ki | 33±n/a nM |
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| Citation |  MacPherson, LJ; Bayburt, EK; Capparelli, MP; Carroll, BJ; Goldstein, R; Justice, MR; Zhu, L; Hu, S; Melton, RA; Fryer, L; Goldberg, RL; Doughty, JR; Spirito, S; Blancuzzi, V; Wilson, D; O'Byrne, EM; Ganu, V; Parker, DT Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits. J Med Chem40:2525-32 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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|
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| BDBM8465 |
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| Unknown |
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| Name: | Unknown |
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| Synonyms: | n/a |
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| Type: | n/a |
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| Mol. Mass.: | 358.43 |
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| Organism: | n/a |
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| Description: | n/a |
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| Residue: | 3 |
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| Sequence: | |
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