| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 4 [368-440] |
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| Ligand | BDBM333405 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | BRD4 AlphaScreen Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Yue, EW; Combs, AP; Buesking, AW Bicyclic heterocycles as bet protein inhibitors US Patent US9737516 Publication Date 8/22/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 4 [368-440] |
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| Name: | Bromodomain-containing protein 4 [368-440] |
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| Synonyms: | BRD4 | BRD4_HUMAN | Bromo domain 2 | Bromodomain-containing protein 4 (BD2) | Bromodomain-containing protein 4 (BRD4) Bromo 2 | Bromodomain-containing protein 4 (BRD4)(BD2) | Bromodomain-containing protein 4 (BRD4)(Bromo 2) | Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2) | Bromodomain-containing protein 4 Bromodomain 2 (BRD4-2) | Bromodomain-containing protein 4 Domain 2 | HUNK1 |
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| Type: | Protein |
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| Mol. Mass.: | 8564.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | BD2 (368-440 aa) of O60885 |
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| Residue: | 73 |
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| Sequence: | KHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFS
NCYKYNPPDHEVV
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| BDBM333405 |
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| n/a |
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| Name | BDBM333405 |
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| Synonyms: | 5-(2,4-Difluorophenoxy)-6-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one | US9737516, Example 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H14F2N4O3 |
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| Mol. Mass. | 408.3577 |
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| SMILES | Cn1cc(-c2cc3[nH]c(=O)[nH]c3cc2Oc2ccc(F)cc2F)c2cc[nH]c2c1=O |
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| Structure | 
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