| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine protease 1 |
|---|
| Ligand | BDBM13291 |
|---|
| Substrate/Competitor | BDBM12500 |
|---|
| Meas. Tech. | Enzyme Assay and Determination of the Inhibition Constants. |
|---|
| pH | 7.5±n/a |
|---|
| Temperature | 295.15±n/a K |
|---|
| Ki | >2900±n/a nM |
|---|
| Citation |  Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Sulfonamidopyrrolidinone factor Xa inhibitors: potency and selectivity enhancements via P-1 and P-4 optimization. J Med Chem42:3572-87 (1999) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
|---|
| |
| Serine protease 1 |
|---|
| Name: | Serine protease 1 |
|---|
| Synonyms: | Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 25790.52 |
|---|
| Organism: | Bos taurus (bovine) |
|---|
| Description: | P00760 |
|---|
| Residue: | 246 |
|---|
| Sequence: | MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVS
AAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLN
SRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQIT
SNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIK
QTIASN
|
|
|
|---|
| BDBM13291 |
|---|
| BDBM12500 |
|---|
| Name | BDBM13291 |
|---|
| Synonyms: | 3-{[(3S)-2-oxo-3-{[4-(pyridin-2-yl)benzene]sulfonamido}pyrrolidin-1-yl]methyl}benzene-1-carboximidamide | 4-Pyridin-2-ylbenzenesulfonic Acid {1-[3-(Aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide | Sulfonamidopyrrolidinone 3d |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H23N5O3S |
|---|
| Mol. Mass. | 449.525 |
|---|
| SMILES | NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc(cc3)-c3ccccn3)C2=O)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
