| Reaction Details |
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 | Report a problem with these data |
| Target | Catenin beta-1 [138-686] |
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| Ligand | BDBM50436058 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Polarization (FP) Assay |
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| Ki | 24390±740 nM |
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| Citation |  Ji, H; Yu, B; Zhang, M; Guo, W Substituted 1H-indazol-1-OL analogs as inhibitors of beta catenin/Tcf protein-protein interactions US Patent US9738628 Publication Date 8/22/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Catenin beta-1 [138-686] |
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| Name: | Catenin beta-1 [138-686] |
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| Synonyms: | Beta-catenin | CTNB1_HUMAN | CTNNB | CTNNB1 |
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| Type: | Protein |
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| Mol. Mass.: | 60127.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 138-686 |
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| Residue: | 549 |
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| Sequence: | NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSA
IVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAIT
TLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILA
SGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRL
VQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMM
VCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKL
LHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQ
QQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGV
LCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVE
LTSSLFRTE
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|
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| BDBM50436058 |
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| n/a |
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| Name | BDBM50436058 |
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| Synonyms: | CHEMBL254381 | PNU-74654 | US9738628, Compound PNU-74654 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16N2O3 |
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| Mol. Mass. | 320.3419 |
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| SMILES | Cc1ccc(\C=N\NC(=O)c2ccccc2Oc2ccccc2)o1 |
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| Structure | 
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