Reaction Details |
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Target | Histamine receptor H3 |
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Ligand | BDBM200837 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Radioligand binding assay |
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Ki | 4.21±0 nM |
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Citation | Gao, Z; Hall, D; Stefany, D Substituted N-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof US Patent US9533995 Publication Date 1/3/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Histamine receptor H3 |
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Name: | Histamine receptor H3 |
Synonyms: | n/a |
Type: | Enzyme |
Mol. Mass.: | 48611.84 |
Organism: | Macaca mulatta (Rhesus macaque) |
Description: | Q865E1 |
Residue: | 445 |
Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGNTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAG
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAAGAEAGETALGGGGGGGSA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEQCWK
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BDBM200837 |
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n/a |
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Name | BDBM200837 |
Synonyms: | 2-[2-((2s,3's)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-pyrimidin-5-yl]-8-oxa-2-aza-spiro[4.5]decan-1-one | US9533995, 16 |
Type | Small organic molecule |
Emp. Form. | C21H31N5O2 |
Mol. Mass. | 385.5031 |
SMILES | C[C@H]1CCCN1[C@H]1CCN(C1)c1ncc(cn1)N1CCC2(CCOCC2)C1=O |r| |
Structure |
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