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TargetIntermediate conductance calcium-activated potassium channel protein 4
LigandBDBM50019905
Substrate/Competitorn/a
Meas. Tech.KCa3.1 Assay
IC50 41±0 nM
Citation Burke MJMcKibben BTschantz MA Fused thiazin-3-ones as KCA3.1 inhibitors US Patent  US9533999 Publication Date 1/3/2017
More Info.:Get all data from this article,  Assay Method
 
Intermediate conductance calcium-activated potassium channel protein 4
Name:Intermediate conductance calcium-activated potassium channel protein 4
Synonyms:IK1 | IKCa1 | KCa4 | Putative Gardos channel | SK4
Type:PROTEIN
Mol. Mass.:47723.22
Organism:Homo sapiens (Human)
Description:ChEMBL_1361891
Residue:427
Sequence:
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFL
VKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPA
PVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYR
SIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDT
LWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHN
FMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRK
LREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLP
EPSQQSK
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  Blast E-value cutoff:
BDBM50019905
n/a
NameBDBM50019905
Synonyms:CHEMBL3287210 | US9533999, ii-4
TypeSmall organic molecule
Emp. Form.C16H13F3N2OS
Mol. Mass.338.347
SMILESCC(N1C(=O)CSc2cccnc12)c1cccc(c1)C(F)(F)F
Structure
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