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TargetCoagulation factor X
LigandBDBM13840
Substrate/CompetitorBDBM12500
Meas. Tech.Factor Xa Inhibition Assay
Ki 68±n/a nM
Citation Matter HDefossa EHeinelt UBlohm PMSchneider DMuller AHerok SSchreuder HLiesum ABrachvogel VLonze PWalser AAl-Obeidi FWildgoose P Design and quantitative structure-activity relationship of 3-amidinobenzyl-1H-indole-2-carboxamides as potent, nonchiral, and selective inhibitors of blood coagulation factor Xa. J Med Chem 45:2749-69 (2002) [PubMed]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Coagulation factor X
Name:Thrombin and coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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BDBM13840
BDBM12500
NameBDBM13840
Synonyms:1-[(3-carbamimidoylphenyl)methyl]-4-hydroxy-N-(naphthalen-1-ylmethyl)-1H-indole-2-carboxamide | 3-amidinobenzylindole carboxamide 24
TypeSmall organic molecule
Emp. Form.C28H24N4O2
Mol. Mass.448.5158
SMILESNC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCc2cccc3ccccc23)c1
Structure
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