Reaction Details |
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Target | Coagulation factor X |
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Ligand | BDBM13853 |
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Substrate/Competitor | BDBM12500 |
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Meas. Tech. | Factor Xa Inhibition Assay |
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Ki | 1720±n/a nM |
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Citation | Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Design and quantitative structure-activity relationship of 3-amidinobenzyl-1H-indole-2-carboxamides as potent, nonchiral, and selective inhibitors of blood coagulation factor Xa. J Med Chem45:2749-69 (2002) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Coagulation factor X |
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Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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BDBM13853 |
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BDBM12500 |
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Name | BDBM13853 |
Synonyms: | 1-[(3-carbamimidoylphenyl)methyl]-4-hydroxy-N-(naphthalen-2-ylmethyl)-1H-indole-2-carboxamide | 3-amidinobenzylindole carboxamide 37 |
Type | Small organic molecule |
Emp. Form. | C28H24N4O2 |
Mol. Mass. | 448.5158 |
SMILES | NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCc2ccc3ccccc3c2)c1 |
Structure |
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