Reaction Details |
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Target | ATP-sensitive inward rectifier potassium channel 1 |
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Ligand | BDBM50121355 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Thallium Flux Assay |
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IC50 | 10.1±n/a nM |
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Citation | Tang, H; Pio, B; Jiang, J; Pasternak, A; Dong, S; Ferguson, II, RD; Guo, ZZ; Chobanian, H; Frie, J; Guo, Y; Wu, Z; Yu, Y; Wang, M Inhibitors of the renal outer medullary potassium channel US Patent US9751881 Publication Date 9/5/2017 |
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More Info.: | Get all data from this article, Assay Method |
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ATP-sensitive inward rectifier potassium channel 1 |
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Name: | ATP-sensitive inward rectifier potassium channel 1 |
Synonyms: | ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 44809.08 |
Organism: | Homo sapiens (Human) |
Description: | gi_223460826 |
Residue: | 391 |
Sequence: | MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM
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BDBM50121355 |
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n/a |
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Name | BDBM50121355 |
Synonyms: | CHEMBL3622112 | US9751881, Example 81 |
Type | Small organic molecule |
Emp. Form. | C26H30N4O3 |
Mol. Mass. | 446.5414 |
SMILES | Cc1cc(cnc1C#N)N1CCC2(C1)CCN(C[C@H](O)c1ccc3C(=O)OCc3c1C)CC2 |r| |
Structure |
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