| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 1 [1-298] |
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| Ligand | BDBM13962 |
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| Substrate/Competitor | BDBM13466 |
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| Meas. Tech. | PTP1B and TCPTP Inhibition Assay |
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| pH | 7.5±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | 24000±1000 nM |
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| Kd | 35000±n/a nM |
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| Comments | Kd derived from 15N-labeled PTP1B |
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| Citation |  Liu, G; Szczepankiewicz, BG; Pei, Z; Janowick, DA; Xin, Z; Hajduk, PJ; Abad-Zapatero, C; Liang, H; Hutchins, CW; Fesik, SW; Ballaron, SJ; Stashko, MA; Lubben, T; Mika, AK; Zinker, BA; Trevillyan, JM; Jirousek, MR Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B. J Med Chem46:2093-103 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 1 [1-298] |
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| Name: | Tyrosine-protein phosphatase non-receptor type 1 [1-298] |
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| Synonyms: | PTN1_HUMAN | PTP-1B | PTP1B | PTPN1 | PTPase 1B | Protein-Tyrosine Phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase, non-receptor type 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 34670.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The catalytic domain of PTP 1B (residues 1-298) was expressed and purified from E. coli. |
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| Residue: | 298 |
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| Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
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| BDBM13962 |
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| BDBM13466 |
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| Name | BDBM13962 |
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| Synonyms: | 2-[(2-Benzylphenyl)oxalylamino]benzoic Acid | 2-[(2-benzylphenyl)amidoformic acid]benzoic acid | Oxalylarylaminobenzoic Acid Analog 8f |
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| Type | Small organic molecule |
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| Emp. Form. | C22H17NO5 |
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| Mol. Mass. | 375.3741 |
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| SMILES | OC(=O)C(=O)N(c1ccccc1Cc1ccccc1)c1ccccc1C(O)=O |
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| Structure | 
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