Ki Summary

Reaction Details

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Target

Tyrosine-protein phosphatase non-receptor type 1 [1-298]

Ligand

BDBM13969

Substrate/Competitor

BDBM13466

Meas. Tech.

PTP1B and TCPTP Inhibition Assay

7.5±n/a

Temperature

295.15±n/a K

9100±n/a nM

Citation

Liu, G; Szczepankiewicz, BG; Pei, Z; Janowick, DA; Xin, Z; Hajduk, PJ; Abad-Zapatero, C; Liang, H; Hutchins, CW; Fesik, SW; Ballaron, SJ; Stashko, MA; Lubben, T; Mika, AK; Zinker, BA; Trevillyan, JM; Jirousek, MR Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B. J Med Chem46:2093-103 (2003) [PubMed] Article

More Info.:

Get all data from this article, Solution Info, Assay Method

Tyrosine-protein phosphatase non-receptor type 1 [1-298]

Name:

Tyrosine-protein phosphatase non-receptor type 1 [1-298]

Synonyms:

Type:

Enzyme

Mol. Mass.:

34670.65

Organism:

Homo sapiens (Human)

Description:

The catalytic domain of PTP 1B (residues 1-298) was expressed and purified from E. coli.

Residue:

298

Sequence:

MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED

BDBM13969

BDBM13466

Name

BDBM13969

Synonyms:

2-({4-[(2S)-2-methanesulfonamido-2-(pentylcarbamoyl)ethyl]phenyl}amidoformic acid)benzoic acid | 2-{[4-(2-(S)-Methanesulfonylamino-2-pentylcarbamoylethyl)phenyl]oxalylamino}benzoic Acid | Oxalylarylaminobenzoic Acid Analog 21

Type

Small organic molecule

Emp. Form.

C24H29N3O8S

Mol. Mass.

519.567

SMILES

CCCCCNC(=O)[C@H](Cc1ccc(cc1)N(C(=O)C(O)=O)c1ccccc1C(O)=O)NS(C)(=O)=O |r|

Structure