Ki Summary

Reaction Details

Report a problem with these data

Target

Tyrosine-protein phosphatase non-receptor type 1 [1-298]

Ligand

BDBM13975

Substrate/Competitor

BDBM13466

Meas. Tech.

PTP1B and TCPTP Inhibition Assay

170±n/a nM

Citation

Liu, G; Szczepankiewicz, BG; Pei, Z; Janowick, DA; Xin, Z; Hajduk, PJ; Abad-Zapatero, C; Liang, H; Hutchins, CW; Fesik, SW; Ballaron, SJ; Stashko, MA; Lubben, T; Mika, AK; Zinker, BA; Trevillyan, JM; Jirousek, MR Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B. J Med Chem46:2093-103 (2003) [PubMed] Article

More Info.:

Get all data from this article, Solution Info, Assay Method

Tyrosine-protein phosphatase non-receptor type 1 [1-298]

Name:

Tyrosine-protein phosphatase non-receptor type 1 [1-298]

Synonyms:

Type:

Enzyme

Mol. Mass.:

34670.65

Organism:

Homo sapiens (Human)

Description:

The catalytic domain of PTP 1B (residues 1-298) was expressed and purified from E. coli.

Residue:

298

Sequence:

MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED

BDBM13975

BDBM13466

Name

BDBM13975

Synonyms:

2-({2-[(1E)-2-carbamoyleth-1-en-1-yl]-4-[(2S)-2-methanesulfonamido-2-(pentylcarbamoyl)ethyl]phenyl}amidoformic acid)benzoic acid | 2-{[2-(2-Carbamoylvinyl)-4-(2-(S)-methanesulfonylamino 2-pentylcarbamoylethyl)phenyl]oxalylamino}-benzoic Acid | Oxalylarylaminobenzoic Acid Analog 17

Type

Small organic molecule

Emp. Form.

C27H32N4O9S

Mol. Mass.

588.629

SMILES

CCCCCNC(=O)[C@H](Cc1ccc(N(C(=O)C(O)=O)c2ccccc2C(O)=O)c(\C=C\C(N)=O)c1)NS(C)(=O)=O |r|

Structure