Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 2 |
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Ligand | BDBM13975 |
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Substrate/Competitor | BDBM13466 |
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Meas. Tech. | PTP1B and TCPTP Inhibition Assay |
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Ki | 160±n/a nM |
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Citation | Liu, G; Szczepankiewicz, BG; Pei, Z; Janowick, DA; Xin, Z; Hajduk, PJ; Abad-Zapatero, C; Liang, H; Hutchins, CW; Fesik, SW; Ballaron, SJ; Stashko, MA; Lubben, T; Mika, AK; Zinker, BA; Trevillyan, JM; Jirousek, MR Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B. J Med Chem46:2093-103 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 2 |
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Name: | Tyrosine-protein phosphatase non-receptor type 2 |
Synonyms: | PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP) |
Type: | Protein |
Mol. Mass.: | 48481.80 |
Organism: | Homo sapiens (Human) |
Description: | P17706 |
Residue: | 415 |
Sequence: | MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVK
LQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKES
VKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTW
PDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGD
DINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPA
FDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKAT
TAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
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BDBM13975 |
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BDBM13466 |
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Name | BDBM13975 |
Synonyms: | 2-({2-[(1E)-2-carbamoyleth-1-en-1-yl]-4-[(2S)-2-methanesulfonamido-2-(pentylcarbamoyl)ethyl]phenyl}amidoformic acid)benzoic acid | 2-{[2-(2-Carbamoylvinyl)-4-(2-(S)-methanesulfonylamino 2-pentylcarbamoylethyl)phenyl]oxalylamino}-benzoic Acid | Oxalylarylaminobenzoic Acid Analog 17 |
Type | Small organic molecule |
Emp. Form. | C27H32N4O9S |
Mol. Mass. | 588.629 |
SMILES | CCCCCNC(=O)[C@H](Cc1ccc(N(C(=O)C(O)=O)c2ccccc2C(O)=O)c(\C=C\C(N)=O)c1)NS(C)(=O)=O |r| |
Structure |
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