| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 2 |
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| Ligand | BDBM13977 |
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| Substrate/Competitor | BDBM13466 |
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| Meas. Tech. | PTP1B and TCPTP Inhibition Assay |
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| pH | 7.5±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | 141000±n/a nM |
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| Citation |  Xin, Z; Liu, G; Abad-Zapatero, C; Pei, Z; Szczepankiewicz, BG; Li, X; Zhang, T; Hutchins, CW; Hajduk, PJ; Ballaron, SJ; Stashko, MA; Lubben, TH; Trevillyan, JM; Jirousek, MR Identification of a monoacid-based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B. Bioorg Med Chem Lett13:3947-50 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 2 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 2 |
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| Synonyms: | PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP) |
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| Type: | Protein |
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| Mol. Mass.: | 48481.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P17706 |
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| Residue: | 415 |
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| Sequence: | MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVK
LQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKES
VKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTW
PDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGD
DINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPA
FDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKAT
TAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
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| BDBM13977 |
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| BDBM13466 |
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| Name | BDBM13977 |
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| Synonyms: | ({4-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-2-({4-[3-hydroxy-2-(methoxycarbonyl)phenoxy]butyl}carbamoyl)ethyl]phenyl}carbamoyl)formic acid | phosphotyrosyl mimetic 8 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H35N3O10 |
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| Mol. Mass. | 573.5916 |
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| SMILES | COC(=O)c1c(O)cccc1OCCCCNC(=O)[C@H](Cc1ccc(NC(=O)C(O)=O)cc1)NC(=O)OC(C)(C)C |r| |
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| Structure | 
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