| Reaction Details |
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 | Report a problem with these data |
| Target | Actin |
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| Ligand | BDBM65515 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Liquid growth assay |
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| Temperature | 303.15±0 K |
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| IC50 | 70±0.0 nM |
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| Citation |  Filipuzzi, I; Thomas, JR; Pries, V; Estoppey, D; Salcius, M; Studer, C; Schirle, M; Hoepfner, D Direct Interaction of Chivosazole F with Actin Elicits Cell Responses Similar to Latrunculin A but Distinct from Chondramide. ACS Chem Biol12:2264-2269 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Actin |
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| Name: | Actin |
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| Synonyms: | ABY1 | ACT1 | ACT_YEAST | Actin | END7 |
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| Type: | Protein |
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| Mol. Mass.: | 41683.13 |
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| Organism: | Baker's yeast |
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| Description: | P60010 |
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| Residue: | 375 |
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| Sequence: | MDSEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGIMVGMGQKDSYVGDEAQS
KRGILTLRYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKSNREKMT
QIMFETFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHAILRIDL
AGRDLTDYLMKILSERGYSFSTTAEREIVRDIKEKLCYVALDFEQEMQTAAQSSSIEKSY
ELPDGQVITIGNERFRAPEALFHPSVLGLESAGIDQTTYNSIMKCDVDVRKELYGNIVMS
GGTTMFPGIAERMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLTTFQQMWISKQ
EYDESGPSIVHHKCF
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| BDBM65515 |
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| n/a |
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| Name | BDBM65515 |
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| Synonyms: | 76343-93-6 | LAT-A | LatA | Latrunculin A |
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| Type | Small organic molecule |
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| Emp. Form. | C22H31NO5S |
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| Mol. Mass. | 421.55 |
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| SMILES | C[C@H]1CC[C@@H]2C[C@H](C[C@@](O)(O2)[C@@H]2CSC(=O)N2)OC(=O)\C=C(C)/CC\C=C\C=C/1 |c:29,t:22,27| |
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| Structure | 
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