Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 1 [1-298] |
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Ligand | BDBM14216 |
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Substrate/Competitor | BDBM13466 |
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Meas. Tech. | Enzymatic Assay |
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pH | 7±n/a |
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Temperature | 295.15±n/a K |
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Ki | 77000±n/a nM |
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Citation | Moretto, AF; Kirincich, SJ; Xu, WX; Smith, MJ; Wan, ZK; Wilson, DP; Follows, BC; Binnun, E; Joseph-McCarthy, D; Foreman, K; Erbe, DV; Zhang, YL; Tam, SK; Tam, SY; Lee, J Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors. Bioorg Med Chem14:2162-77 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 1 [1-298] |
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Name: | Tyrosine-protein phosphatase non-receptor type 1 [1-298] |
Synonyms: | PTN1_HUMAN | PTP-1B | PTP1B | PTPN1 | PTPase 1B | Protein-Tyrosine Phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase, non-receptor type 1 |
Type: | Enzyme |
Mol. Mass.: | 34670.65 |
Organism: | Homo sapiens (Human) |
Description: | The catalytic domain of PTP 1B (residues 1-298) was expressed and purified from E. coli. |
Residue: | 298 |
Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
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BDBM14216 |
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BDBM13466 |
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Name | BDBM14216 |
Synonyms: | 3-(carboxymethoxy)thieno[3,2-b]pyridine-2-carboxylic acid | bicyclic scaffold compound 6 |
Type | Small organic molecule |
Emp. Form. | C10H7NO5S |
Mol. Mass. | 253.231 |
SMILES | OC(=O)COc1c(sc2cccnc12)C(O)=O |
Structure |
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