| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mast/stem cell growth factor receptor Kit [D816V] |
|---|
| Ligand | BDBM342416 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical Assay |
|---|
| Ki | 500±n/a nM |
|---|
| Citation |  Lin, J; Pham, P; Buell, J; Spevak, W Compounds and methods for kinase modulation, and indications therefor US Patent US9771369 Publication Date 9/26/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mast/stem cell growth factor receptor Kit [D816V] |
|---|
| Name: | Mast/stem cell growth factor receptor Kit [D816V] |
|---|
| Synonyms: | KIT | KIT_HUMAN | Mast/stem cell growth factor receptor Kit (D816V) | Mast/stem cell growth factor receptor Kit 1 (D816V) | SCFR | Tyrosine-protein kinase Kit (Kit)(D816V) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 109854.42 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human Kit D816V mutant |
|---|
| Residue: | 976 |
|---|
| Sequence: | MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD
PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV
DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH
RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS
SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN
VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE
DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR
LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS
SAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIV
MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF
GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC
TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE
YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM
AFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPES
IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY
DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV
GSTASSSQPLLVHDDV
|
|
|
|---|
| BDBM342416 |
|---|
| n/a |
|---|
| Name | BDBM342416 |
|---|
| Synonyms: | 4-[4-[4-[5-[4-(difluoromethoxy)phenyl]- 4-methyl-1H-imidazol-2-yl]-4-methyl-1- piperidyl]-7H-pyrrolo[2,3-d]pyrimidin- 6-yl]benzamide | US9771369, Compound P-3253 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H29F2N7O2 |
|---|
| Mol. Mass. | 557.5938 |
|---|
| SMILES | Cc1nc([nH]c1-c1ccc(OC(F)F)cc1)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(cc1)C(N)=O |
|---|
| Structure | 
|
|---|
Search and Browse
