| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor VII |
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| Ligand | BDBM14495 |
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| Substrate/Competitor | BDBM14496 |
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| Meas. Tech. | TF-VIIa Assay |
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| pH | 8±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 118±n/a nM |
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| Citation |  Parlow, JJ; Kurumbail, RG; Stegeman, RA; Stevens, AM; Stallings, WC; South, MS Design, synthesis, and crystal structure of selective 2-pyridone tissue factor VIIa inhibitors. J Med Chem46:4696-701 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Coagulation factor VII |
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| Name: | Coagulation factor VII |
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| Synonyms: | Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator |
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| Type: | Enzyme |
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| Mol. Mass.: | 51599.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 466 |
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| Sequence: | MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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| BDBM14495 |
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| BDBM14496 |
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| Name | BDBM14495 |
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| Synonyms: | 2-Pyridone 14a | 3-amino-5-[1-({[(4-carbamimidoylphenyl)methyl]carbamoyl}methyl)-6-oxo-5-(propan-2-ylamino)-1,6-dihydropyridin-2-yl]benzoic acid | 3-amino-5-[1-[2-({4-[amino(imino)methyl]benzyl}amino)-2-oxoethyl]-5-(isopropylamino)-6-oxo-1,6-dihydropyridin-2-yl]benzoic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28N6O4 |
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| Mol. Mass. | 476.5276 |
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| SMILES | CC(C)Nc1ccc(-c2cc(N)cc(c2)C(O)=O)n(CC(=O)NCc2ccc(cc2)C(N)=N)c1=O |
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| Structure | 
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