Reaction Details |
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Target | Histone deacetylase 4 |
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Ligand | BDBM345231 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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IC50 | 48.0±n/a nM |
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Citation | Dominguez, C; Muñoz-Sanjuán, I; Maillard, M; Raphy, G; Haughan, AF; Luckhurst, CA; Jarvis, RE; Bürli, RW; Breccia, P; Wishart, G; Hughes, SJ; Allen, DR; Penrose, SD Histone deacetylase inhibitors and compositions and methods of use thereof US Patent US9783488 Publication Date 10/10/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 4 |
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Name: | Histone deacetylase 4 |
Synonyms: | Cereblon/Histone deacetylase 4 | HD4 | HDAC4 | HDAC4_HUMAN | Histone acetylase 4(HDAC4) | Human HDAC4 | KIAA0288 |
Type: | Enzyme |
Mol. Mass.: | 119049.39 |
Organism: | Homo sapiens (Human) |
Description: | P56524 |
Residue: | 1084 |
Sequence: | MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP
VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA
MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL
NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP
LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP
SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA
TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL
EQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHL
VIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPY
LDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQ
RIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDT
LMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT
LLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVE
LVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWD
VHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDP
PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL
MGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKV
MEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEE
EPPL
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BDBM345231 |
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n/a |
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Name | BDBM345231 |
Synonyms: | (1S,3S*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3-(quinolin-6- yl)cyclopentanecarboxamide | US9783488, Example 84 |
Type | Small organic molecule |
Emp. Form. | C22H21FN2O2 |
Mol. Mass. | 364.4127 |
SMILES | Cc1c(F)cccc1[C@@]1(CC[C@@H](C1)c1ccc2ncccc2c1)C(=O)NO |r| |
Structure |
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