| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM14597 |
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| Substrate/Competitor | BDBM12500 |
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| Meas. Tech. | Factor Xa Assay |
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| pH | 8±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | >30000±n/a nM |
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| Citation |  Parlow, JJ; Stevens, AM; Stegeman, RA; Stallings, WC; Kurumbail, RG; South, MS Synthesis and crystal structures of substituted benzenes and benzoquinones as tissue factor VIIa inhibitors. J Med Chem46:4297-312 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM14597 |
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| BDBM12500 |
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| Name | BDBM14597 |
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| Synonyms: | 2-[3-Amino-3-fluoro-4-(isopropylamino)-1,1-biphenyl-2-yl]-N-{4-[amino(imino)methyl]benzyl}acetamide | 2-[6-(3-aminophenyl)-2-fluoro-3-(propan-2-ylamino)phenyl]-N-[(4-carbamimidoylphenyl)methyl]acetamide | CHEMBL125781 | Substituted Benzene Analog 50c |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28FN5O |
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| Mol. Mass. | 433.5211 |
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| SMILES | CC(C)Nc1ccc(-c2cccc(N)c2)c(CC(=O)NCc2ccc(cc2)C(N)=N)c1F |
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| Structure | 
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