| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM14702 |
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| Substrate/Competitor | BDBM14700 |
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| Meas. Tech. | DHODH Inhibition Assay |
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| Ki | 15100±n/a nM |
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| IC50 | 123300±n/a nM |
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| Citation |  Heikkila, T; Ramsey, C; Davies, M; Galtier, C; Stead, AM; Johnson, AP; Fishwick, CW; Boa, AN; McConkey, GA Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase. J Med Chem50:186-91 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 42881.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q02127 |
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| Residue: | 395 |
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| Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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| BDBM14702 |
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| BDBM14700 |
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| Name | BDBM14702 |
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| Synonyms: | 1,3-diethyl 2-[(1H-indazol-5-ylamino)methylidene]propanedioate | 2-[(1H-Indazol-5-ylamino)-methylene]-malonic acid diethyl ester | bicyclic compound 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H17N3O4 |
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| Mol. Mass. | 303.3132 |
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| SMILES | CCOC(=O)C(C=Nc1ccc2n[nH]cc2c1)C(=O)OCC |w:7.7| |
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| Structure | 
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