Reaction Details |
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Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Ligand | BDBM14706 |
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Substrate/Competitor | BDBM14700 |
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Meas. Tech. | DHODH Inhibition Assay |
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IC50 | >500000±n/a nM |
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Citation | Heikkila, T; Ramsey, C; Davies, M; Galtier, C; Stead, AM; Johnson, AP; Fishwick, CW; Boa, AN; McConkey, GA Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase. J Med Chem50:186-91 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Dihydroorotate dehydrogenase (quinone), mitochondrial |
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Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 42881.33 |
Organism: | Homo sapiens (Human) |
Description: | Q02127 |
Residue: | 395 |
Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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BDBM14706 |
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BDBM14700 |
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Name | BDBM14706 |
Synonyms: | Ethyl 3-(biphenyl-4-ylamino)-2-cyanoacrylate | biphenyl compound 11 | ethyl (2Z)-2-cyano-3-[(4-phenylphenyl)amino]prop-2-enoate |
Type | Small organic molecule |
Emp. Form. | C18H16N2O2 |
Mol. Mass. | 292.3318 |
SMILES | CCOC(=O)C(C=Nc1ccc(cc1)-c1ccccc1)C#N |w:7.7| |
Structure |
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