Reaction Details |
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Target | Tyrosine-protein kinase SYK |
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Ligand | BDBM345149 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Inhibition |
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IC50 | 89.0±n/a nM |
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Citation | Fyfe, MC; Meghani, P; Thom, SM Kinase inhibitors US Patent US9783556 Publication Date 10/10/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase SYK |
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Name: | Tyrosine-protein kinase SYK |
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
Type: | Enzyme |
Mol. Mass.: | 72079.99 |
Organism: | Homo sapiens (Human) |
Description: | P43405 |
Residue: | 635 |
Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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BDBM345149 |
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n/a |
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Name | BDBM345149 |
Synonyms: | 1-(4-((2-((3-Methoxy-5-(2-(2-(2-methoxyethoxyl)ethoxy)ethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)urea | US9783556, Example 21 |
Type | Small organic molecule |
Emp. Form. | C42H49N7O7Si |
Mol. Mass. | 791.9667 |
SMILES | COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)[Si](C)(C)C)c4ccccc34)n2)cc(OC)c1 |
Structure |
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