| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysine-specific demethylase 4C |
|---|
| Ligand | BDBM347129 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | JMJD2C Assay |
|---|
| IC50 | <100±n/a nM |
|---|
| Citation |  Boloor, A; Kanouni, T; Stafford, JA; Veal, JM; Wallace, MB Histone demethylase inhibitors US Patent US10202381 Publication Date 2/12/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysine-specific demethylase 4C |
|---|
| Name: | Lysine-specific demethylase 4C |
|---|
| Synonyms: | GASC-1 protein | GASC1 | Gene amplified in squamous cell carcinoma 1 protein | JHDM3C | JMJD2C | JmjC domain-containing histone demethylation protein 3C | Jumonji domain-containing protein 2C | KDM4C | KDM4C_HUMAN | KIAA0780 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 119979.01 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9H3R0 |
|---|
| Residue: | 1056 |
|---|
| Sequence: | MEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQC
YDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLE
RKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYF
GMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFL
RHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWID
YGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPASTPEVKAWL
QRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTDDLKVSEKSEAAV
KLRNTEASSEEESSASRMQVEQNLSDHIKLSGNSCLSTSVTEDIKTEDDKAYAYRSVPSI
SSEADDSIPLSSGYEKPEKSDPSELSWPKSPESCSSVAESNGVLTEGEESDVESHGNGLE
PGEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSPMTLVKQQAPSDEELPEV
LSIEEEVEETESWAKPLIHLWQTKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSS
NEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAK
CCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAV
AVPEVRFTNVPERTQIDVGRIPLQRLKLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTC
AHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYSCRVM
AVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGS
NIAHMYQVEFEDGSQIAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADIIQGER
KRQRVLSSRFKNEYVADPVYRTFLKSSFQKKCQKRQ
|
|
|
|---|
| BDBM347129 |
|---|
| n/a |
|---|
| Name | BDBM347129 |
|---|
| Synonyms: | -(4-(methyl(3-(4-methylpiperazin-1-yl)-4- (2,2,2-trifluoroethoxy)phenyl)amino) phenoxy)pyrido[3,4-d]pyrimidin-4-ol | US10202381, Example 136 | US10208039, Example 136 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H27F3N6O3 |
|---|
| Mol. Mass. | 540.5369 |
|---|
| SMILES | CN(c1ccc(Oc2nc(O)c3ccncc3n2)cc1)c1ccc(OCC(F)(F)F)c(c1)N1CCN(C)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
