| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 4 |
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| Ligand | BDBM210152 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7.2±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 1.00±n/a nM |
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| Comments | extracted |
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| Citation |  Bhide, RS; Duncia, JV; Hynes, J; Nair, SK; Pitts, WJ; Kumar, SR; Gardner, DS; Murugesan, N; Paidi, VR; Santella, JB; Sistla, R; Wu, H Bicyclic heterocycle substituted pyridyl compounds useful as kinase modulators US Patent US9546153 Publication Date 1/17/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-1 receptor-associated kinase 4 |
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| Name: | Interleukin-1 receptor-associated kinase 4 |
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| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
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| Type: | Protein |
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| Mol. Mass.: | 51519.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NWZ3 |
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| Residue: | 460 |
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| Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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| BDBM210152 |
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| n/a |
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| Name | BDBM210152 |
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| Synonyms: | US9546153, ex. 288 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26F2N6O2 |
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| Mol. Mass. | 432.4669 |
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| SMILES | CC(C)Nc1cc(Nc2ccn3ncc(F)c3c2)ncc1C(=O)NC[C@@H](F)C(C)(C)O |r| |
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| Structure | 
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