Reaction Details |
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Target | Dipeptidyl peptidase 9 |
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Ligand | BDBM15515 |
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Substrate/Competitor | BDBM11057 |
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Meas. Tech. | DPP Inhibition Assay |
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Ki | >3000±n/a nM |
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Citation | Pei, Z; Li, X; von Geldern, TW; Longenecker, K; Pireh, D; Stewart, KD; Backes, BJ; Lai, C; Lubben, TH; Ballaron, SJ; Beno, DW; Kempf-Grote, AJ; Sham, HL; Trevillyan, JM Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors. J Med Chem50:1983-7 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Dipeptidyl peptidase 9 |
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Name: | Dipeptidyl peptidase 9 |
Synonyms: | DPP9 | DPP9_HUMAN | DPRP-2 | DPRP2 | Dipeptidyl peptidase 9 (DDP9) | Dipeptidyl peptidase 9 (DPP-9) | Dipeptidyl peptidase 9 (DPP9) | Dipeptidyl peptidase IV-related protein 2 | Dipeptidyl peptidase IX | Dipeptidyl peptidase IX (DDP-IX) | Dipeptidyl peptidase-like protein 9 |
Type: | Enzyme |
Mol. Mass.: | 98260.70 |
Organism: | Homo sapiens (Human) |
Description: | Q86TI2 |
Residue: | 863 |
Sequence: | MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQ
KTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGV
YSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEI
KTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAG
VATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKT
DSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRD
GKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVW
INVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFK
CPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVR
LTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAAS
CPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIK
YLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFID
LSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHG
YEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERH
SIRCPESGEHYEVTLLHFLQEYL
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BDBM15515 |
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BDBM11057 |
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Name | BDBM15515 |
Synonyms: | 3-(2-((4R,5R)-5-amino-2-oxo-4-(2,4,5-trifluorophenyl)piperidin-1-yl)ethyl)benzoic acid | 3-{2-[(4R,5R)-5-amino-2-oxo-4-(2,4,5-trifluorophenyl)piperidin-1-yl]ethyl}benzoic acid | Piperidinone-Constrained Phenethylamine 35 |
Type | Small organic molecule |
Emp. Form. | C20H19F3N2O3 |
Mol. Mass. | 392.3717 |
SMILES | N[C@H]1CN(CCc2cccc(c2)C(O)=O)C(=O)C[C@@H]1c1cc(F)c(F)cc1F |r| |
Structure |
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