Reaction Details |
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Target | Beta-secretase 1 |
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Ligand | BDBM15779 |
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Substrate/Competitor | BACE-1 Peptide Substrate |
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Meas. Tech. | BACE-1 Inhibition Assay |
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pH | 5±n/a |
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Temperature | 295.15±n/a K |
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IC50 | 94000±n/a nM |
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Citation | Congreve, M; Aharony, D; Albert, J; Callaghan, O; Campbell, J; Carr, RA; Chessari, G; Cowan, S; Edwards, PD; Frederickson, M; McMenamin, R; Murray, CW; Patel, S; Wallis, N Application of fragment screening by X-ray crystallography to the discovery of aminopyridines as inhibitors of beta-secretase. J Med Chem50:1124-32 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Beta-secretase 1 |
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Name: | Beta-secretase 1 |
Synonyms: | ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1) |
Type: | Protein |
Mol. Mass.: | 55755.10 |
Organism: | Homo sapiens (Human) |
Description: | P56817 |
Residue: | 501 |
Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRQQHDDFADDISLLK
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BDBM15779 |
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BACE-1 Peptide Substrate |
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Name: | BACE-1 Peptide Substrate |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 2721.34 |
Organism: | n/a |
Description: | n/a |
Residue: | 23 |
Sequence: | R-E(EDANS)-E-V-N-L-*D-A-E-F-K(DABCYL)-R-OH
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