Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 1 [1-298] |
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Ligand | BDBM15816 |
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Substrate/Competitor | BDBM13466 |
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Meas. Tech. | PTP1B and TCPTP Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 295.15±n/a K |
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Ki | 710±280 nM |
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Citation | Xin, Z; Oost, TK; Abad-Zapatero, C; Hajduk, PJ; Pei, Z; Szczepankiewicz, BG; Hutchins, CW; Ballaron, SJ; Stashko, MA; Lubben, T; Trevillyan, JM; Jirousek, MR; Liu, G Potent, selective inhibitors of protein tyrosine phosphatase 1B. Bioorg Med Chem Lett13:1887-90 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 1 [1-298] |
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Name: | Tyrosine-protein phosphatase non-receptor type 1 [1-298] |
Synonyms: | PTN1_HUMAN | PTP-1B | PTP1B | PTPN1 | PTPase 1B | Protein-Tyrosine Phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase, non-receptor type 1 |
Type: | Enzyme |
Mol. Mass.: | 34670.65 |
Organism: | Homo sapiens (Human) |
Description: | The catalytic domain of PTP 1B (residues 1-298) was expressed and purified from E. coli. |
Residue: | 298 |
Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
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BDBM15816 |
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BDBM13466 |
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Name | BDBM15816 |
Synonyms: | 1:1 mixture of diastereomers | 2-[(4-{2-[(4-{[(1S)-5-amino-1-carboxypentyl]carbamoyl}butyl)carbamoyl]-2-acetamidoethyl}-2-ethylphenyl)amidoformic acid]benzoic acid | oxalyl-aryl-amino benzoic acid-based inhibitor 16 |
Type | Small organic molecule |
Emp. Form. | C33H43N5O10 |
Mol. Mass. | 669.722 |
SMILES | CCc1cc(CC(NC(C)=O)C(=O)NCCCCC(=O)N[C@@H](CCCCN)C(O)=O)ccc1N(C(=O)C(O)=O)c1ccccc1C(O)=O |r| |
Structure |
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