| Reaction Details |
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 | Report a problem with these data |
| Target | ATP-sensitive inward rectifier potassium channel 1 |
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| Ligand | BDBM350299 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Thallium Flux Assay |
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| IC50 | 7.00±n/a nM |
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| Citation |  Pasternak, A; Davies, I; Ding, F; Jiang, J; Dong, S; Gu, X; Suzuki, T; Vacca, JP; Pu, Z; Xu, S Inhibitors of the renal outer medullary potassium channel US Patent US10208064 Publication Date 2/19/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| ATP-sensitive inward rectifier potassium channel 1 |
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| Name: | ATP-sensitive inward rectifier potassium channel 1 |
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| Synonyms: | ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44809.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_223460826 |
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| Residue: | 391 |
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| Sequence: | MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM
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| BDBM350299 |
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| n/a |
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| Name | BDBM350299 |
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| Synonyms: | US10208064, Example 18 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N6O4 |
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| Mol. Mass. | 462.501 |
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| SMILES | C[C@@H]1CC2(CCN(C[C@@H](O)c3ccc4c(ccc5nnnn45)c3)CC2)C(=O)N1C1=CC(=O)OC1 |r,t:33| |
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| Structure | 
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