| Reaction Details |
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 | Report a problem with these data |
| Target | Urokinase-type plasminogen activator |
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| Ligand | BDBM16139 |
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| Substrate/Competitor | BDBM14716 |
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| Meas. Tech. | Determination of Inhibitor Potency and Selectivity |
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| pH | 8.1±n/a |
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| Temperature | 310.15±n/a K |
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| Ki | 48±n/a nM |
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| Km | 90000±n/a nM |
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| Citation |  Fish, PV; Barber, CG; Brown, DG; Butt, R; Collis, MG; Dickinson, RP; Henry, BT; Horne, VA; Huggins, JP; King, E; O'gara, M; McCleverty, D; McIntosh, F; Phillips, C; Webster, R Selective Urokinase-Type Plasminogen Activator Inhibitors. 4. 1-(7-Sulfonamidoisoquinolinyl)guanidines. J Med Chem50:2341-51 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Urokinase-type plasminogen activator |
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| Name: | Urokinase-type plasminogen activator |
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| Synonyms: | 3.4.21.73 | PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator chain B | Urokinase-type plasminogen activator long chain A | Urokinase-type plasminogen activator short chain A | Urokinase-type plasminogen activator/surface receptor | uPA |
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| Type: | Enzyme |
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| Mol. Mass.: | 48528.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00749 |
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| Residue: | 431 |
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| Sequence: | MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
YCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
SHTKEENGLAL
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| BDBM16139 |
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| BDBM14716 |
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| Name | BDBM16139 |
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| Synonyms: | 1-guanidino-7-sulfonamidoisoquinoline 13 | 2-({4-chloro-1-[(diaminomethylidene)amino]isoquinoline-7-}sulfonamido)acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C12H12ClN5O4S |
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| Mol. Mass. | 357.773 |
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| SMILES | [#7]\[#6](-[#7])=[#7]/c1ncc(Cl)c2ccc(cc12)S(=O)(=O)[#7]-[#6]-[#6](-[#8])=O |
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| Structure | 
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