Reaction Details |
| Report a problem with these data |
Target | Urokinase-type plasminogen activator |
---|
Ligand | BDBM16163 |
---|
Substrate/Competitor | BDBM14716 |
---|
Meas. Tech. | Determination of Inhibitor Potency and Selectivity |
---|
Ki | 54±n/a nM |
---|
Citation | Fish, PV; Barber, CG; Brown, DG; Butt, R; Collis, MG; Dickinson, RP; Henry, BT; Horne, VA; Huggins, JP; King, E; O'gara, M; McCleverty, D; McIntosh, F; Phillips, C; Webster, R Selective Urokinase-Type Plasminogen Activator Inhibitors. 4. 1-(7-Sulfonamidoisoquinolinyl)guanidines. J Med Chem50:2341-51 (2007) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Urokinase-type plasminogen activator |
---|
Name: | Urokinase-type plasminogen activator |
Synonyms: | 3.4.21.73 | PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator chain B | Urokinase-type plasminogen activator long chain A | Urokinase-type plasminogen activator short chain A | Urokinase-type plasminogen activator/surface receptor | uPA |
Type: | Enzyme |
Mol. Mass.: | 48528.62 |
Organism: | Homo sapiens (Human) |
Description: | P00749 |
Residue: | 431 |
Sequence: | MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
YCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
SHTKEENGLAL
|
|
|
BDBM16163 |
---|
BDBM14716 |
---|
Name | BDBM16163 |
Synonyms: | (2R)-1-({4-chloro-1-[(diaminomethylidene)amino]isoquinoline-7-}sulfonyl)pyrrolidine-2-carboxamide | cyclic deriv. 37 |
Type | Small organic molecule |
Emp. Form. | C15H17ClN6O3S |
Mol. Mass. | 396.852 |
SMILES | [#7]\[#6](-[#7])=[#7]/c1ncc(Cl)c2ccc(cc12)S(=O)(=O)[#7]-1-[#6]-[#6]-[#6]-[#6@@H]-1-[#6](-[#7])=O |r| |
Structure |
|