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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM350860 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | <250±n/a nM | ||
| Citation |  Wang, X; Liu, J; Zhang, W; Frye, S; Kireev, D Pyrrolopyrimidine compounds for the treatment of cancer US Patent US9795606 Publication Date 10/24/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
| ||
| BDBM350860 | |||
| n/a | |||
| Name | BDBM350860 | ||
| Synonyms: | UNC2370A | US10004755, Compound UNC2370A | US9795606, B19 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H37N5O2 | ||
| Mol. Mass. | 475.6257 | ||
| SMILES | O[C@H]1CCC(CC1)n1cc(-c2ccc(CN3CCOCC3)cc2)c2cnc(NCCC3CC3)nc12 |r,wU:7.7,wD:1.0,(4.07,-8.34,;3.67,-6.85,;4.76,-5.76,;4.36,-4.27,;2.87,-3.88,;1.78,-4.96,;2.18,-6.45,;2.47,-2.39,;3.38,-1.14,;2.47,.1,;2.87,1.59,;4.36,1.99,;4.76,3.48,;3.67,4.57,;4.07,6.05,;5.56,6.45,;6.65,5.36,;8.13,5.76,;8.53,7.25,;7.44,8.34,;5.96,7.94,;2.18,4.17,;1.78,2.68,;1.01,-.37,;-.32,.4,;-1.66,-.37,;-1.66,-1.91,;-2.99,-2.68,;-4.32,-1.91,;-5.66,-2.68,;-6.99,-1.91,;-7.76,-.58,;-8.53,-1.91,;-.32,-2.68,;1.01,-1.91,)| | ||
| Structure | 
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