Reaction Details |
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Target | Enoyl-[acyl-carrier-protein] reductase [NADH] |
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Ligand | BDBM16298 |
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Substrate/Competitor | BDBM16293 |
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Meas. Tech. | Measurement of Inhibition Constants |
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pH | 6.8±n/a |
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Temperature | 295.15±n/a K |
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Ki | 1.1±0.2 nM |
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Km | 29000±n/a nM |
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Citation | Sullivan, TJ; Truglio, JJ; Boyne, ME; Novichenok, P; Zhang, X; Stratton, CF; Li, HJ; Kaur, T; Amin, A; Johnson, F; Slayden, RA; Kisker, C; Tonge, PJ High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis. ACS Chem Biol1:43-53 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Enoyl-[acyl-carrier-protein] reductase [NADH] |
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Name: | Enoyl-[acyl-carrier-protein] reductase [NADH] |
Synonyms: | Enoyl-ACP Reductase (InhA) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-[acyl-carrier-protein] reductase [NADH] | INHA_MYCTU | NADH-dependent enoyl-ACP reductase | inhA |
Type: | Enzyme |
Mol. Mass.: | 28526.00 |
Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Description: | P9WGR1 |
Residue: | 269 |
Sequence: | MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPL
LELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGI
HISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAG
KYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAK
TVCALLSDWLPATTGDIIYADGGAHTQLL
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BDBM16298 |
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BDBM16293 |
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Name | BDBM16298 |
Synonyms: | 5-Octyl-2-phenoxy-phenol | 5-heptyl-2-phenoxylphenol | 5-octyl-2-phenoxyphenol | 8PP | AIDS227448 | CHEMBL505886 | PT05 |
Type | Small organic molecule |
Emp. Form. | C20H26O2 |
Mol. Mass. | 298.4192 |
SMILES | CCCCCCCCc1ccc(Oc2ccccc2)c(O)c1 |
Structure |
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