| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 9 |
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| Ligand | BDBM351691 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HTRF Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Inhibitors of Jun N-terminal kinase US Patent US9796706 Publication Date 10/24/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 9 |
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| Name: | Mitogen-activated protein kinase 9 |
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| Synonyms: | JNK-55 | JNK2 | JNK2/JNK3 | MAPK9 | MK09_HUMAN | Mitogen-Activated Protein Kinase 9 (JNK2) | Mitogen-activated protein kinase 8/9 | PRKM9 | SAPK1A | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2 | c-Jun N-terminal kinase 2 (JNK2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 48131.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). |
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| Residue: | 424 |
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| Sequence: | MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP
FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ
LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK
MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV
MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL
EGCR
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| BDBM351691 |
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| n/a |
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| Name | BDBM351691 |
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| Synonyms: | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(5-oxo-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-4(5H)-yl)acetamide | US9796706, Compound 135 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H9BrF3N7O2S |
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| Mol. Mass. | 488.242 |
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| SMILES | FC(F)(F)c1cc2n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c(=O)ccn2n1 |
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| Structure | 
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