| Reaction Details |
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 | Report a problem with these data |
| Target | Proteinase-activated receptor 4 |
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| Ligand | BDBM176259 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PAR4 FLIPR assay |
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| Temperature | 298.15±n/a K |
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| EC50 | 0.270±n/a nM |
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| Comments | extracted |
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| Citation |  Banville, J; Remillard, R; Ruediger, EH; Deon, DH; Gagnon, M; Dube, L; Guy, J; Priestley, ES; Posy, SL; Maxwell, BD; Wong, PC; Lawrence, RM; Miller, MM Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation US Patent US10047103 Publication Date 8/14/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteinase-activated receptor 4 |
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| Name: | Proteinase-activated receptor 4 |
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| Synonyms: | Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3 |
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| Type: | Protein |
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| Mol. Mass.: | 41145.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96RI0 |
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| Residue: | 385 |
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| Sequence: | MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDT
LELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAA
ADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVH
PLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASH
WQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSN
LLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSP
GDTVASKASAEGGSRGMGTHSSLLQ
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| BDBM176259 |
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| n/a |
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| Name | BDBM176259 |
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| Synonyms: | US10047103, 292 | US9688695, 292 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H26N6O5S2 |
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| Mol. Mass. | 614.695 |
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| SMILES | CCN(CCC#N)C(=O)c1ccc(cc1)-c1nc(COc2cc(OC)cc3oc(cc23)-c2cn3nc(OC)sc3n2)cs1 |
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| Structure | 
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