| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin S |
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| Ligand | BDBM352420 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| Ki | 160±n/a nM |
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| Citation |  Nardi, A; Ratcliffe, P; Craan, T; Hertrampf, T; Lesch, B; Steinhagen, H 3-oxo-tetrahydro-furo[3,2-b]pyrrol-4(5H)-yl) derivatives II US Patent US9802947 Publication Date 10/31/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin S |
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| Name: | Cathepsin S |
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| Synonyms: | CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein |
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| Type: | Protein |
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| Mol. Mass.: | 37507.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25774 |
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| Residue: | 331 |
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| Sequence: | MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
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| BDBM352420 |
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| n/a |
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| Name | BDBM352420 |
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| Synonyms: | N—((S)-2-((3aS,6S,6aS)-6-chloro-3-oxotetrahydro-2H-furo[3,2-b]pyrrol-4(5H)-yl)-1-cyclopentyl-2-oxoethyl)-5-(pyridin-4-yl)thiophene-2-carboxamide | US9802947, Compound Example 8 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24ClN3O4S |
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| Mol. Mass. | 473.972 |
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| SMILES | Cl[C@H]1CN([C@H]2[C@@H]1OCC2=O)C(=O)[C@@H](NC(=O)c1ccc(s1)-c1ccncc1)C1CCCC1 |r| |
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| Structure | 
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