Ki Summary

Reaction Details

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Target

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Ligand

BDBM354659

Substrate/Competitor

n/a

Meas. Tech.

HTRF assay

IC50

5.5±n/a nM

Citation

Armani, E; Amari, G; Blackaby, W; Van De Poel, H; Baker-Glenn, C; Trivedi, N Aminoester derivatives US Patent US9809582 Publication Date 11/7/2017

More Info.:

Get all data from this article, Assay Method

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Name:

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Synonyms:

Type:

Protein

Mol. Mass.:

83318.87

Organism:

Homo sapiens (Human)

Description:

Q07343

Residue:

736

Sequence:

MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
ETDIDIATEDKSPVDT

BDBM354659

n/a

Name

BDBM354659

Synonyms:

US9809582, Example 1 | [(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)ethyl] 5-[[[3-oxo-2-phenyl-3-[(3R)-quinuclidin-3-yl]oxy-propyl]amino]methyl]thiophene-2-carboxylate

Type

Small organic molecule

Emp. Form.

C37H39Cl2N3O7S

Mol. Mass.

740.692

SMILES

COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1ccc(CNCC(C(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)s1 |r,wU:10.22,wD:35.36,(-6.42,-8.73,;-5.09,-9.5,;-3.76,-8.73,;-2.42,-9.5,;-1.09,-8.73,;-1.09,-7.19,;-2.42,-6.42,;-3.76,-7.19,;-5.09,-6.42,;-6.42,-7.19,;.24,-6.42,;1.58,-7.19,;2.91,-6.42,;4.24,-7.19,;4.24,-8.73,;5.58,-6.42,;5.58,-4.88,;6.91,-4.11,;4.24,-4.11,;2.91,-4.88,;1.58,-4.11,;.24,-4.88,;-1.09,-4.11,;-2.42,-4.88,;-1.09,-2.57,;-2.34,-1.66,;-1.86,-.2,;-.32,-.2,;.45,1.14,;-.32,2.47,;.45,3.81,;-.32,5.14,;.77,6.23,;.37,7.72,;2.26,5.83,;3.35,6.92,;4.83,6.52,;5.92,7.61,;5.52,9.1,;4.04,9.5,;2.95,8.41,;4.43,8.8,;4.43,7.26,;-1.81,5.54,;-2.21,7.03,;-3.69,7.42,;-4.78,6.34,;-4.38,4.85,;-2.9,4.45,;.16,-1.66,)|

Structure