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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
| Ligand | BDBM354661 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | HTRF assay | ||
| IC50 | 5.5±n/a nM | ||
| Citation |  Armani, E; Amari, G; Blackaby, W; Van De Poel, H; Baker-Glenn, C; Trivedi, N Aminoester derivatives US Patent US9809582 Publication Date 11/7/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | |||
| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
| Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) | ||
| Type: | Protein | ||
| Mol. Mass.: | 83318.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q07343 | ||
| Residue: | 736 | ||
| Sequence: |
| ||
| BDBM354661 | |||
| n/a | |||
| Name | BDBM354661 | ||
| Synonyms: | US9809582, Example 3 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C40H43Cl2N3O7S | ||
| Mol. Mass. | 780.756 | ||
| SMILES | COc1ccc(cc1OC)[C@H](Cc1c(Cl)c[n+]([O-])cc1Cl)OC(=O)c1ccc(CN2CCC(CC2)(C(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)s1 |r,wU:10.22,wD:38.40,(-6.45,-9.72,;-5.11,-10.49,;-3.78,-9.72,;-2.44,-10.49,;-1.11,-9.72,;-1.11,-8.18,;-2.44,-7.41,;-3.78,-8.18,;-5.11,-7.41,;-6.45,-8.18,;.22,-7.41,;1.56,-8.18,;2.89,-7.41,;2.89,-5.87,;1.56,-5.1,;4.22,-5.1,;5.56,-5.87,;6.89,-5.1,;5.56,-7.41,;4.22,-8.18,;4.22,-9.72,;.22,-5.87,;-1.11,-5.1,;-2.44,-5.87,;-1.11,-3.56,;-2.36,-2.66,;-1.88,-1.19,;-.34,-1.19,;.43,.14,;-.34,1.48,;.43,2.81,;-.34,4.14,;-1.88,4.14,;-2.65,2.81,;-1.88,1.48,;-1.48,5.63,;-2.57,6.72,;.01,6.03,;.4,7.52,;1.89,7.92,;2.29,9.4,;1.2,10.49,;-.29,10.09,;-.69,8.61,;.8,8.21,;.8,9.75,;-3.37,4.54,;-3.77,6.03,;-5.25,6.43,;-6.34,5.34,;-5.94,3.85,;-4.46,3.45,;.13,-2.66,)| | ||
| Structure | 
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